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Dr. Paul Savage, M.D.

Founder, Lead Physician

Dr. Savage is a world leader in integrative medicine, revolutionizing the approach to regenerative, integrative care. He founded Agenixs, the first integrative medicine concierge medical practice in the United States, with a focus on white-glove, customized treatment. With more than 20 years in the field treating thousands of patients, Dr. Savage draws the country’s most ambitious and competitive professionals — powerful executives, top athletes, celebrities, influential entrepreneurs — and is a nationally sought-after lecturer and consultant. Dr. Savage’s unique approach brings together innovative research, the most up-to-date methods of evaluation and treatment, and his own vast experience — with powerful, proven results. His goal: to guide each patient to good health, vitality, stamina, beauty, and happiness — throughout life’s journeys.

A Personal Journey

At 37 years old, Dr. Savage was a successful ER/trauma physician at Grace Hospital in Detroit. He also weighed 267 pounds, smoked, felt tired, anxious, and unwell all the time, and suffered from high cholesterol, high blood pressure, pre-diabetes and stress. His doctor prescribed medication to address these issues, but Dr. Savage felt that there had to be a better solution. A born investigator with a keen sense of curiosity driven by the determination to improve his health, he researched and explored every method and treatment that promised positive results — lifestyle changes, nutrition, supplements, hormones, IV Therapy, Stem Cell Therapy, and more.

Dr. Savage’s journey led him to embrace integrative medicine — an evidence-based approach that considers the doctor/patient relationship a partnership; focuses on the whole person; and uses an array of scientific disciplines to heal illness and disease and help people regain and maintain optimum health.

Walking the Walk

Twenty years later, Dr. Savage is healthy, strong, vibrant, and passionate about his life’s work. He uses a combination of traditional and integrative medicine to keep himself — and his patients — in top physical and mental condition. Dr. Savage constantly seeks to expand his own knowledge base, investigating the latest medical research and technologies and integrating it into his practice when appropriate. Extraordinarily experienced, knowledgeable, and devoted to his patients, Dr. Savage is the ultimate partner in creating the life you want.

Education, Experience, and Accreditations

  • A graduate of the University of Michigan School of Medicine
  • ER/trauma physician at Grace Hospital/Detroit, 15 years
  • Board-certified by the American Academy of Integrative Medicine
  • Fellow of Integrative and Regenerative Medicine
  • Certified by George Washington University Metabolic Medicine Program
  • Accredited by the Ageless Institute
  • Active member of Suzanne Somers’ Forever Health Program
  • Member of the Independent Research Board Approvedby the Institute for the Advancement of Medicine.
  • Featured in Suzanne Somers’ bestseller “Ageless”
Dr. Savage is also frequently called upon to provide expert insights on integrative medicine and hormone therapy to major news media, including BusinessWeek, NBC, WGN, Fox News, Women’s World, and the Chicago Tribune.

Affiliations & Accreditations

University of Michigan School of Medicine
Fellow of Emergency Medicine
George Washington University Metabolic Medical Institute
Fellow of Metabolic Medicine
University of Southern Florida Stem Cell Fellowship
Fellow of Stem Cell Therapy
Aesthetic Institute
Stem Cell Accreditation
International Institute for the Advancement of Medicine
Independent Research Board
American Academy of Anti-Aging Medicine
Fellow of Integrative and Regenerative Medicine

Affiliations & Accrediations

University of Michigan
Medical School
Board and Fellow of Anti-Aging and
Regenerative Medicine
George Washington University Metabolic Medical Institute
Fellow of Metabolic Medicine
University of Southern Florida Stem Cell Fellowship
Fellow of Stem Cell Therapy
Ageless Aesthetic Institute
Stem Cell Accreditation
International Institute for the Advancement of Medicine
Independent Research Board
Bioidentical Hormone Doctors Nationwide
Recommended Physician
Forever Health
Suzanne Somers' Recommended Physician 
American Academy of Anti-Aging
Board and Fellow of Anti-Aging and Regenerative Medicine

Testosterone Therapy

Men need testosterone to live well—not just for optimal mental and physical health, but to prevent chronic illnesses. With years of experience evaluating and treating low T, Dr. Savage customizes each treatment, using testosterone pellets or injections to optimize effective and safe improvements in health, energy, stamina, sex drive, and performance.

Testosterone Pellets

Testosterone pellets are the only method of testosterone therapy that delivers consistent, physiologic levels of testosterone, thus avoiding fluctuations in hormone levels—and in mood and energy—that can be caused by other methods of delivery. Lasting from four to six months, pellets are the most effective, safest, and convenient form of testosterone replacement.

How Pellets Work
Each Tic-Tac-sized pellet contains crystalline testosterone. During a brief and painless in-office procedure, pellets are implanted under the skin in the upper buttock area. The incision is so small it can be closed with a piece of tape. Once implanted, the pellets deliver a stable, steady dose of testosterone.

Proven Results
Studies show that pellets are the superior form of testosterone replacement therapy in increasing lean body mass—muscle strength and bone density—and decreasing fat mass; and in improving libido, sexual response, and performance. Proven benefits include increased strength, coordination and physical performance, and improvement in concentration and memory. The change starts within days. There is more data to support the use of pellets than any other method of testosterone therapy.


Injected into the thigh, glute, or deltoid muscles, testosterone is absorbed directly into the bloodstream. One advantage of injections is flexibility—dosages can be changed with each injection, if necessary, to achieve optimal concentrations. Administered weekly, biweekly, or bi-monthly, testosterone injections can boost energy, sex drive, and quality of erections; increase lean muscle mass; decrease body fat; boost memory and concentration; and relieve anxiety and depression.

Testosterone Therapy: Safe and Effective

What You Should Know
  • Low testosterone is a well-established medical condition that negatively affects male sexuality, reproduction, general health, and quality of life.
  • Symptoms and signs of low testosterone occur as a result of low levels of testosterone and may benefit from treatment, regardless of whether there is an identified underlying origin.
  • Testosterone therapy for men with low testosterone is effective and evidence-based.
  • There is no established testosterone level that reliably distinguishes those men who will respond to treatment from those who will not.
  • There is no scientific basis for withholding testosterone therapy to older adult males.
  • Testosterone therapy does not increase the risk of prostate cancer.
  • Testosterone therapy does not increase the risks of heart attacks or heart disease.
  • Testosterone therapy has benefits for cardiometabolic disease, including diabetes
While there are risks associated with testosterone therapy, these are generally related to improper dosing; these risks include acne, blood clots, hair loss, and breast development. With decades of experience in administering appropriate testosterone therapy, we encounter these side effects in our patients infrequently.